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Home >> Antibodies >> BAG2 Antibody

BAG2 Antibody [clone 8F11G2] (RQ7328)

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  Catalog No Formulation Size Price (USD)  
Image RQ7328 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human K562 cells with BAG2 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BAG2 antibody.
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Flow cytometry testing of human K562 cells with BAG2 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= BAG2 antibody.
Western blot testing of 1) human Jurkat, 2) human HeLa, 3) human HepG2, 4) human K562 and 5) mouse liver tissue lysate with BAG2 antibody. Predicted molecular weight ~22 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 8F11G2
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O95816
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This BAG2 antibody is available for research use only.
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Description

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Application Notes

Optimal dilution of the BAG2 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids M1-N211) was used as the immunogen for the BAG2 antibody.

Storage

After reconstitution, the BAG2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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