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Home >> Antibodies >> BAF47 Antibody / Integrase interactor 1 / SMARCB1

BAF47 Antibody / Integrase interactor 1 / SMARCB1 [clone rINI1/8850] (V4861)

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  Catalog No Formulation Size Price (USD)  
Image V4861-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4861-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4861SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human prostate tissue with BAF47 antibody (clone rINI1/8850) HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human prostate tissue with BAF47 antibody (clone rINI1/8850) HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human prostate tissue with BAF47 antibody (clone rINI1/8850) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Rabbit IgG, kappa
Clone Name rINI1/8850
Purity Protein A/G affinity
UniProt Q12824
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This BAF47 antibody is available for research use only.
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Description

The INI-1 gene which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.

Application Notes

Optimal dilution of the BAF47 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the BAF47 antibody.

Storage

Aliquot the BAF47 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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