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Home >> Antibodies >> BACE1 Antibody

BACE1 Antibody (F50758)

  Catalog No Formulation Size Price (USD)  
Image F50758-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F50758-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
IHC analysis of FFPE human brain tissue stained with BACE1 antibody
Western blot analysis of BACE1 antibody and mouse heart tissue lysate.
Availability 1-3 business days
Species Reactivity Human, Mouse
Predicted Reactivity Rat, Bovine
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P56817
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Limitations This BACE1 antibody is available for research use only.
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Description

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [UniProt]

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the BACE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 38-70 from the human protein was used as the immunogen for this BACE1 antibody.

Storage

Store at 4oC for up to one month. For long term, aliquot the BACE1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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