- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
B Lymphocyte Antigen CD19 Antibody [clone CD19/13031R] (V6035)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V6035-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
|
|
V6035-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
|
|
V6035SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CD19/13031R |
| UniProt | P15391 |
| Localization | Cell membrane, Membrane raft |
| Applications | ELISA : |
| Limitations | This CD19/B lymphocyte antigen CD19 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
CD19 antibody recognizes CD19, a B lymphocyte surface glycoprotein that functions as a critical coreceptor in B cell receptor signaling. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) is designed for specific detection of CD19 in research applications focused on B cell biology and lymphoid malignancies. CD19 is a member of the immunoglobulin superfamily and is expressed from early pro-B cell stages through mature peripheral B lymphocytes, where it localizes to the plasma membrane. By forming a signaling complex with CD21 and CD81, CD19 amplifies antigen receptor-mediated signaling and lowers the activation threshold of B cells.
The CD19 gene is located on chromosome 16p11.2 and encodes a type I transmembrane protein containing two extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail enriched in tyrosine residues that become phosphorylated upon B cell activation. These phosphorylation events recruit signaling molecules such as PI3K and adaptor proteins, driving downstream pathways that regulate B cell proliferation, differentiation, and survival. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) supports investigations into normal B cell development and dysregulated signaling associated with immune disorders and hematologic malignancies.
In normal human tissues, CD19 expression is restricted to B lineage cells within bone marrow, lymph node, tonsil, and spleen. Terminally differentiated plasma cells typically exhibit reduced or absent CD19 expression, reflecting late-stage B cell maturation. Because of its lineage specificity and stable membrane expression, CD19 serves as a reliable pan-B cell marker in immunologic and translational research settings.
Aberrant CD19 expression characterizes most B cell malignancies, including B cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and various non-Hodgkin lymphomas. CD19 has also become a major therapeutic target in immunotherapy strategies such as chimeric antigen receptor T cell approaches. Accurate detection of CD19 is therefore essential for studies of tumor biology, immune targeting, and therapeutic development.
Clone CD19/13031R is a recombinant rabbit monoclonal antibody engineered for defined sequence identity and consistent lot-to-lot performance. Recombinant production supports reliable binding characteristics and strong membranous staining of CD19-positive B cells with minimal background in non-B cell populations. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) provides dependable performance for researchers investigating B cell distribution, immune regulation, and B cell-driven disease processes.
Optimal dilution of the CD19/B lymphocyte antigen CD19 antibody should be determined by the researcher.
Recombinant human CD19 protein was used as the immuongen for the CD19/B lymphocyte antigen CD19 antibody.
CD19/B lymphocyte antigen CD19 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
