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Home >> Antibodies >> B-cell maturation protein Antibody / BCMA / CD269 / TNFRSF17

B-cell maturation protein Antibody / BCMA / CD269 / TNFRSF17 [clone CD269/8190R] (V4425)

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  Catalog No Formulation Size Price (USD)  
Image V4425-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4425-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4425SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human tonsil tissue with B-cell maturation protein antibody (clone CD269/8190R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human tonsil tissue with B-cell maturation protein antibody (clone CD269/8190R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CD269/8190R
Purity Protein A/G affinity
UniProt Q02223
Localization Cell surface
Applications ELISA (Order BSA-free format for coating) :
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This B-cell maturation protein antibody is available for research use only.
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Description

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Application Notes

Optimal dilution of the B-cell maturation protein antibody should be determined by the researcher.

Immunogen

A recombinant human protein fragment (within amino acids 1-184) was used as the immunogen for the B-cell maturation protein antibody.

Storage

Aliquot the B-cell maturation protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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