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Home >> Antibodies >> AXIN2 Antibody

AXIN2 Antibody (F49172)

  Catalog No Formulation Size Price (USD)  
Image F49172-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F49172-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
AXIN2 antibody western blot analysis in Jurkat lysate
AXIN2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue
AXIN2 antibody flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control (left histogram). FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9Y2T1
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Flow Cytometry : 1:10-1:50
Limitations This AXIN2 antibody is available for research use only.
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Description

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Application Notes

Titration of the AXIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.

Storage

Aliquot the AXIN2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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