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Home >> Antibodies >> AXIN1 Antibody

AXIN1 Antibody (F45423)

  Catalog No Formulation Size Price (USD)  
Image F45423-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F45423-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
AXIN1 antibody western blot analysis in MDA-MB453 lysate. Predicted molecular weight: 95-110 kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O15169
Applications Western blot : 1:1000
Limitations This AXIN1 antibody is available for research use only.
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Description

AXIN1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. [UniProt]

Application Notes

Titration of the AXIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 330-359 from the human protein was used as the immunogen for this AXIN1 antibody.

Storage

Aliquot the AXIN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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