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Home >> Antibodies >> Aurkb Antibody

Aurkb Antibody (F44415)

  Catalog No Formulation Size Price (USD)  
Image F44415-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F44415-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Aurkb antibody western blot analysis in Ramos lysate. Predicted molecular weight: 33-39 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse
Predicted Reactivity Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O70126
Applications Western blot : 1:1000
Limitations This Aurkb antibody is available for research use only.
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Description

Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).

Application Notes

Titration of the Aurkb antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody.

Storage

Aliquot the Aurkb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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