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Home >> Antibodies >> ATRX Antibody / RAD54

ATRX Antibody / RAD54 [clone 23c] (V3808)

  Catalog No Formulation Size Price (USD)  
Image V3808-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 429
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V3808-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V3808SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
SDS-PAGE analysis of purified, BSA-free ATRX antibody (clone 23c) as confirmation of integrity and purity.
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 23c
Purity Protein G affinity chromatography
UniProt P46100
Localization Nuclear
Applications ELISA : 2-4ug/ml for coating (order BSA/sodium azide free format)
Limitations This ATRX antibody is available for research use only.
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Description

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 α to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha-thalassemia or ATRX syndrome.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ATRX antibody to be titered up or down for optimal performance.

Immunogen

Recombinant human ATRX protein was used as the immunogen for this ATRX antibody.

Storage

Store the ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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