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Home >> Antibodies >> ATP7B Antibody

ATP7B Antibody (RQ6944)

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  Catalog No Formulation Size Price (USD)  
Image RQ6944 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Immunofluorescent staining of FFPE human Caco-2 cells with ATP7B antibody (green) and DAPI nuclear stain (blue). HIER: steam section in pH6 citrate buffer for 20 min.
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Immunofluorescent staining of FFPE human Caco-2 cells with ATP7B antibody (green) and DAPI nuclear stain (blue). HIER: steam section in pH6 citrate buffer for 20 min.
Western blot testing of 1) human HepG2, 2) rat liver and 3) mouse kidney lysate with ATP7B antibody. Expected molecular weight: 140-157 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P35670
Localization Cytoplasmic
Applications Western blot : 0.5-1 ug/ml
Immunofluorescence : 5ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This ATP7B antibody is available for research use only.
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  • Applications : WB, IHC-P, FACS, IF
    Reactivity : Human, Mouse

Description

ATPase, Cu++ transporting, beta polypeptide (Wilson disease) protein, also called ATP7B, is an ATPase that transports copper. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two putative copper-binding sites. ATP7B is mapped to 13q14.3. This protein functions as a monomer, exporting copper out of the cells. When copper levels are in excess, ATP7B redistributes to a vesicular compartment near the biliary canalicular membranes for elimination of excess copper into bile, and it is transported along liver cell microtubules via interaction with the p62 dynactin subunit.

Application Notes

Optimal dilution of the ATP7B antibody should be determined by the researcher.

Immunogen

Recombinant human ATP7B protein (amino acids Q241-K495) was used as the immunogen for the ATP7B antibody.

Storage

After reconstitution, the ATP7B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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