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Home >> Antibodies >> ATG12 Antibody

ATG12 Antibody (F41508)

  Catalog No Formulation Size Price (USD)  
Image F41508-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F41508-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of ATG12 antibody and MCF-7 lysate.
Western blot analysis of ATG12 antibody and mouse brain tissue lysate
Mouse leukaemic monocyte macrophage cells treated with vinblastine for 1 hr. ATG12 antibody detected punctuate staining indicative of nascent autophagic vacuole structures.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O94817
Applications Western blot : 1:1000
Immunofluorescence : 1:50-1:100
Limitations This ATG12 antibody is available for research use only.
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Description

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

APG12L/ATG12 is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.

Application Notes

Titration of the ATG12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1-50 from the human protein was used as the immunogen for this ATG12 antibody.

Storage

Aliquot the ATG12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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