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Home >> Antibodies >> ATF6 beta Antibody

ATF6 beta Antibody (F49022)

  Catalog No Formulation Size Price (USD)  
Image F49022-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F49022-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of lysate from (1) HeLa, (2) HepG2 and (3) human placenta tissue lysate using ATF6 beta antibody at 1:1000. Predicted molecular weight: 75~90kDa.
ATF6 beta antibody western blot analysis in (1) mouse NIH3T3, (2) hamster CHO and (3) mouse cerebellum lysate
Immunohistochemical analysis of paraffin-embedded human prostate section using ATF6 beta antibody at 1:25.
Immunohistochemical analysis of paraffin-embedded human kidney section using ATF6 beta antibody at 1:25.
Availability 1-3 business days
Species Reactivity Human, Hamster, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q99941
Applications IHC (Paraffin) : 1:25
Western blot : 1:1000
Limitations This ATF6 beta antibody is available for research use only.
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Description

ATF6 beta is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus.

Application Notes

Titration of the ATF6 beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 560-589 from the human protein was used as the immunogen for this ATF6 beta antibody.

Storage

Aliquot the ATF6 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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