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Home >> Antibodies >> ATF4 Antibody

ATF4 Antibody (F42021)

  Catalog No Formulation Size Price (USD)  
Image F42021-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42021-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
ATF4 antibody western blot analysis in (1) Jurkat and (2) MCF-7 lysate. Predicted molecular weight ~39kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P18848
Applications Western blot : 1:1000
Limitations This ATF4 antibody is available for research use only.
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Description

ATF4 is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. [UniProt]

Application Notes

Titration of the ATF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 171-198 from the human protein was used as the immunogen for this ATF4 antibody.

Storage

Aliquot the ATF4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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