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Home >> Antibodies >> ATF2 Antibody / Activating Transcription Factor 2

ATF2 Antibody / Activating Transcription Factor 2 [clone IA-1] (RQ5447)

  Catalog No Formulation Size Price (USD)  
Image RQ5447 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ug 359
Western blot testing of human HeLa cell lysate with ATF2 antibody. Expected molecular weight: 65-70 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name IA-1
Purity Affinity purified
UniProt P15336
Applications Western blot : 1:500-1:2000
Limitations This ATF2 antibody is available for research use only.
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Description

The ATF2 gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. [RefSeq]

Application Notes

Optimal dilution of the ATF2 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Activating Transcription Factor 2 was used as the immunogen for the ATF2 antibody.

Storage

Store the ATF2 antibody at -20oC.

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