- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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ATF1 Antibody / Activating Transcription Factor 1 Antibody recognizes Activating Transcription Factor 1 (ATF1), a basic leucine zipper DNA-binding protein that belongs to the CREB/ATF family of transcription factors. ATF1 regulates gene expression by binding cyclic AMP response elements within target promoters after dimerizing with itself or related proteins such as CREB and CREM. Its transcriptional activity is controlled by phosphorylation downstream of cyclic AMP, protein kinase A and mitogen-activated protein kinase signaling pathways, allowing ATF1 to coordinate diverse cellular responses. NSJ Bioreagents offers ATF1 antibodies for research on transcriptional regulation, signal transduction and disease mechanisms.
Activating Transcription Factor 1 participates in the regulation of genes involved in proliferation, differentiation, metabolism, apoptosis and cellular stress responses. The protein has been implicated in oncogenic signaling through recurrent gene fusions, including EWSR1-ATF1 and FUS-ATF1, which are associated with several human malignancies. ATF1 also contributes to immune regulation, neuronal function and adaptation to environmental stress, making it an important research target across multiple biological disciplines.
Researchers frequently investigate ATF1 expression to understand how extracellular signals regulate transcriptional networks and downstream biological responses. Studies examine interactions between Activating Transcription Factor 1 and other CREB family proteins, transcriptional coactivators and chromatin-associated regulators. Measuring ATF1 abundance and localization provides valuable insight into cell signaling, transcriptional control and molecular mechanisms underlying normal physiology and disease.
An ATF1 Antibody is an effective reagent for detecting Activating Transcription Factor 1 by Western blotting, immunohistochemistry, immunofluorescence, flow cytometry and related immunoassays. An Activating Transcription Factor 1 Antibody supports studies of transcriptional regulation, CREB signaling, cellular stress responses and gene expression.
For additional information on ATF1 biology, CREB family signaling and transcriptional regulation, visit our ATF1 Antibody / CREB Family Transcription Factor Antibody page.
Optimal dilution of the ATF1 Antibody / Activating Transcription Factor 1 Antibody should be determined by the researcher.
Recombinant human protein (amino acids M1-V271) was used as the immunogen for the ATF1 antibody.
After reconstitution, the ATF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
ATF1 antibody, Activating Transcription Factor 1 antibody, Cyclic AMP Dependent Transcription Factor ATF1 antibody, CREB Family Transcription Factor antibody
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