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- Tel: 858.663.9055
- Email: info@nsjbio.com
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.
Titration of the ASIC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 23-52 from the human protein was used as the immunogen for this ASIC4 antibody.
Aliquot the ASIC4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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