- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Aryl Hydrocarbon Receptor Repressor Antibody / AHRR (RQ8461)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8461 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | A9YTQ3 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells ELISA : 0.1-0.5ug/ml |
| Limitations | This Aryl Hydrocarbon Receptor Repressor antibody is available for research use only. |
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Aryl Hydrocarbon Receptor Repressor antibody targets Aryl hydrocarbon receptor repressor, encoded by the AHRR gene. Aryl hydrocarbon receptor repressor is a nuclear and cytoplasmic protein belonging to the basic helix-loop-helix PAS family of transcriptional regulators. It functions primarily as a feedback inhibitor of aryl hydrocarbon receptor signaling by competing with AHR for binding partners and regulatory DNA elements, thereby restraining pathway activation following ligand stimulation.
Aryl hydrocarbon receptor repressor plays a critical role in maintaining homeostasis within the aryl hydrocarbon receptor signaling cascade, which governs cellular responses to environmental xenobiotics, endogenous metabolites, and dietary ligands. Upon activation of AHR, transcription of AHRR is induced, establishing a negative feedback loop that limits excessive or prolonged transcriptional responses. An Aryl Hydrocarbon Receptor Repressor antibody supports studies focused on transcriptional regulation, environmental response pathways, and feedback control mechanisms.
AHRR expression is detected across a range of tissues, with notable relevance in immune cells, epithelial compartments, and developmental contexts. Its expression pattern often reflects prior or ongoing AHR pathway activation, consistent with its role as an inducible suppressor rather than a constitutively active transcription factor. Subcellular localization of Aryl hydrocarbon receptor repressor is predominantly nuclear, aligning with its transcriptional repressive function, although cytoplasmic localization can also be observed depending on cell type and signaling state.
From a disease relevance perspective, dysregulation of Aryl hydrocarbon receptor repressor has been associated with cancer, immune-related disorders, and environmentally influenced disease processes. Reduced expression or epigenetic silencing of AHRR can impair normal feedback inhibition of AHR signaling, resulting in sustained transcriptional activity that may promote abnormal proliferation, altered differentiation, or inflammatory signaling. These observations highlight AHRR as an important regulatory checkpoint in environmentally responsive transcriptional networks.
At the molecular level, Aryl hydrocarbon receptor repressor contains conserved PAS domains that mediate protein-protein interactions required for transcriptional repression. Its functional behavior can be influenced by cellular context, interaction partners, and post-translational regulatory mechanisms, which may affect experimental readouts without altering the underlying protein sequence. Aryl Hydrocarbon Receptor Repressor antibody reagents support research into transcriptional repression and xenobiotic response signaling, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the Aryl Hydrocarbon Receptor Repressor antibody should be determined by the researcher.
An E.coli-derived human recombinant protein (amino acids K410-D665) was used as the immunogen for the Aryl Hydrocarbon Receptor Repressor antibody.
After reconstitution, the Aryl Hydrocarbon Receptor Repressor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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