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Home >> Antibodies >> Aryl hydrocarbon Receptor Antibody (AHR)

Aryl hydrocarbon Receptor Antibody (AHR) (R30876)

  Catalog No Formulation Size Price (USD)  
Image R30876 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Aryl hydrocarbon Receptor antibody and human samples 1: PANC; 2: HeLa; 3: MCF-7; 4: HT1080 cell lysate. Predicted molecular weight ~ 95kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P35869
Applications Western blot : 0.5-1ug/ml
Limitations This Aryl hydrocarbon Receptor antibody is available for research use only.
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Description

Aryl hydrocarbon receptor, also called AHR and bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. It is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr-/- or Er-alpha -/- ovariectomized mice. CD4-positive cells from mice lacking the recepter developed Th17 responses but failed to produce IL-22 and did not show enhanced Th17 development. Activation of Aryl hydrocarbon receptor during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in -/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Aryl hydrocarbon Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 832-848 (HPSEARPFPDLTSSGFL-human) were used as the immunogen for this Aryl hydrocarbon Receptor antibody.

Storage

After reconstitution, the Aryl hydrocarbon Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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