ARPC1B Antibody / Actin-related protein 2/3 complex subunit 1B (RQ4972)

Description

ARPC1B, or Actin-related protein 2/3 complex subunit 1B, is a vital component of the Arp2/3 complex, which plays a central role in the regulation of the actin cytoskeleton. This complex initiates the formation of branched actin networks, contributing to various cellular processes such as cell migration, endocytosis, and immune synapse formation. ARPC1B is one of two isoforms of the ARPC1 subunit, the other being ARPC1A, and is known to be predominantly expressed in hematopoietic cells, where it supports specialized immune functions.

Deficiency or mutation of ARPC1B has been associated with immunodeficiency syndromes characterized by platelet abnormalities, recurrent infections, and immune dysregulation. Because of its critical function in cytoskeletal organization and immune cell dynamics, ARPC1B is increasingly studied in immunology and cell biology. Multiple isoforms of ARPC1B have been reported, suggesting possible differential roles across tissues or developmental stages.

The ARPC1B antibody is an essential tool for researchers studying actin remodeling, immune cell signaling, and cytoskeletal architecture. A high-quality ARPC1B antibody enables accurate detection of the protein in western blot, immunofluorescence, and immunohistochemistry assays. NSJ Bioreagents offers a validated ARPC1B antibody suitable for various research applications, ensuring specificity and reproducibility in experimental workflows.

Application Notes

Optimal dilution of the ARPC1B antibody should be determined by the researcher.

Immunogen

Amino acids Q293-K372 from the human protein were used as the immunogen for the ARPC1B antibody.

Storage

Store the ARPC1B antibody at -20oC.