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Home >> Antibodies >> Aromatase Antibody / CYP19A1

Aromatase Antibody / CYP19A1 (R31219)

  Catalog No Formulation Size Price (USD)  
Image R31219 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Aromatase antibody and Lane 1: rat brain; 2: (r) thymus; 3: (r) kidney tissue lysate. Predicted molecular weight ~58 kDa.
IHC-P: Aromatase antibody testing of rat brain tissue
Availability 1-3 business days
Species Reactivity Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P22443
Localization Membrane
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Aromatase antibody is available for research use only.
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Description

CYP19A1, also called Aromatase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, Aromatase is responsible for the aromatization of androgens into estrogens. The enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Aromatase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of rat Aromatase (LKRFHVKTLQKRCIENMPKNND) was used as the immunogen for this Aromatase antibody.

Storage

After reconstitution, the Aromatase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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