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Home >> Antibodies >> Aromatase Antibody / CYP19A1

Aromatase Antibody / CYP19A1 (R30562)

  Catalog No Formulation Size Price (USD)  
Image R30562 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Aromatase antibody and human placenta lysate. Predicted molecular weight ~58 kDa.
IHC-P: Aromatase antibody testing of human placenta tissue
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P11511
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Aromatase antibody is available for research use only.
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Description

Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons. By in situ hybridization, the ARO gene is mapped to 15q21.1. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development. Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, which can cause gynecomastia.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Aromatase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human Aromatase (KNMLEMIFTPRNSDRCLEH) was used as the immunogen for this Aromatase antibody.

Storage

After reconstitution, the Aromatase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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