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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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ARG2 Antibody / Arginine Metabolism Antibody recognizes ARG2, a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to ornithine and urea. ARG2 is one of two mammalian arginase isoforms and is also known as Arginase 2 or Arginase II. In contrast to the predominantly hepatic and cytosolic ARG1 isoform, ARG2 contains an N-terminal mitochondrial targeting sequence and is widely expressed in extrahepatic tissues, with particularly prominent expression in kidney. Its ability to regulate cellular L-arginine utilization places ARG2 at the intersection of amino acid metabolism, mitochondrial function and multiple signaling pathways influenced by arginine availability.
ARG2 competes for L-arginine with nitric oxide synthases, which use the same amino acid as a substrate for nitric oxide production. Changes in arginase activity can therefore alter the availability of L-arginine for nitric oxide synthesis. This relationship has been extensively investigated in vascular biology, where increased ARG2 activity may contribute to reduced nitric oxide bioavailability and altered endothelial function. An ARG2 Antibody can support studies examining the relationship between arginine metabolism, nitric oxide regulation, vascular homeostasis and metabolic stress.
ARG2-mediated production of ornithine also connects arginine utilization with downstream metabolic pathways. Ornithine can serve as a precursor for polyamine synthesis and proline production, linking arginase activity to cellular proliferation, tissue remodeling and extracellular matrix biology. These metabolic relationships extend the biological significance of ARG2 beyond urea formation and make the protein relevant to studies of nutrient utilization and metabolic adaptation. As an Arginine Metabolism Antibody target, ARG2 provides a useful means of investigating how changes in amino acid metabolism influence cellular physiology.
Arginine metabolism is also an important component of immune regulation and tumor biology. Availability of extracellular and intracellular arginine can influence immune cell activation, proliferation and effector function. ARG2 expression has been investigated in immune cell populations and in tumor-associated environments where altered nutrient utilization can affect interactions between malignant and immune cells. These relationships make ARG2 relevant to studies of immunometabolism, inflammatory signaling and metabolic mechanisms that contribute to tumor progression and immune regulation.
The mitochondrial localization and extrahepatic distribution of ARG2 distinguish it from ARG1 and provide opportunities to investigate compartment-specific regulation of L-arginine metabolism. Its connections to nitric oxide synthesis, ornithine production, vascular biology and immune cell metabolism make ARG2 relevant across metabolic, cardiovascular, immunological and cancer research. NSJ Bioreagents supplies antibodies to ARG2 and other proteins involved in amino acid metabolism. An ARG2 Antibody can support studies of arginine metabolism, mitochondrial function, nitric oxide regulation, immunometabolism and metabolic signaling.
For additional information on ARG2 and its roles in mitochondrial arginine metabolism, nitric oxide regulation and cellular metabolism, see our Arginase 2 Antibody page.
Optimal dilution of the ARG2 Antibody / Arginine Metabolism Antibody should be determined by the researcher.
Recombinant human protein (amino acids E43-A320) was used as the immunogen for the ARG2 antibody.
After reconstitution, the ARG2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
ARG2 antibody, Arginine metabolism antibody, Arginase 2 antibody, Arginase II antibody, Mitochondrial arginase antibody, Kidney-type arginase antibody
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