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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ARF1 Rabbit Polyclonal Antibody / ADP-ribosylation factor 1 (F49371)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
F49371-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
|
|
F49371-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Bovine, Primate, Xenopus |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P84077 |
| Applications | Western Blot : 1:1000 IHC (Paraffin) : 1:50-1:100 |
| Limitations | This ARF1 Rabbit Polyclonal Antibody is available for research use only. |
|
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ARF1 is a GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). [UniProt]
For an antibody with an established history of published use targeting the same protein, see our ARF1 Antibody 1A9/5 / ADP-Ribosylation Factor 1 Antibody.
Titration of the ARF1 Rabbit Polyclonal Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 80-106 from the human protein was used as the immunogen for this ARF1 Rabbit Polyclonal Antibody.
Aliquot the ARF1 Rabbit Polyclonal Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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