- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
ADP-Ribosylation Factor 1 Antibody ARF1/2117 / ARF1 Monoclonal Antibody recognizes ARF1, a small GTP-binding protein belonging to the ADP-ribosylation factor family within the Ras superfamily. ARF1 functions as a molecular switch by cycling between GDP-bound inactive and GTP-bound active states. This regulated cycle allows ARF1 to coordinate membrane trafficking, vesicle formation and maintenance of intracellular organelle structure, particularly within the Golgi apparatus and secretory pathway.
Activation of ARF1 is controlled by guanine nucleotide exchange factors, while GTPase-activating proteins promote conversion back to the GDP-bound state. Active ARF1 associates with cellular membranes and recruits coat proteins and other effectors required for cargo transport. A particularly well-characterized function is recruitment of COPI coat components to Golgi membranes, facilitating retrograde trafficking within the Golgi and between the Golgi apparatus and endoplasmic reticulum.
ADP-Ribosylation Factor 1 also contributes to membrane remodeling through regulation of lipid-modifying enzymes and membrane composition. These activities connect ARF1 with cargo sorting, Golgi organization and the formation of membrane environments required for intracellular transport. Through interactions with multiple effectors, ARF1 can coordinate changes in membrane structure with movement of proteins and lipids between cellular compartments.
ARF1-dependent processes also intersect with pathways involved in cell proliferation, metabolism and cytoskeletal organization. Altered regulation of ARF1 has therefore been investigated in cancer and other disease models involving changes in intracellular trafficking or cellular signaling. NSJ Bioreagents offers clone ARF1/2117 as a monoclonal reagent for research into ARF1 expression, Golgi biology and membrane trafficking.
An ADP-Ribosylation Factor 1 Antibody provides a reagent for investigating vesicular transport and Golgi-associated processes, while an ARF1 Monoclonal Antibody provides gene-based terminology for studies of this small regulatory GTPase.
For an antibody with an established history of published use targeting the same protein, see our ARF1 Antibody 1A9/5 / ADP-Ribosylation Factor 1 Antibody.
Optimal dilution of the ADP-Ribosylation Factor 1 Antibody ARF1/2117 / ARF1 Monoclonal Antibody should be determined by the researcher.
A recombinant full-length human ARF1 protein was used as the immunogen for this ADP-Ribosylation Factor 1 Antibody ARF1/2117.
Store the ADP-Ribosylation Factor 1 Antibody ARF1/2117 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
ARF1 antibody, ARF-1 antibody, ADP Ribosylation Factor 1 antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.