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Home >> Antibodies >> AR Antibody

AR Antibody (F42850)

  Catalog No Formulation Size Price (USD)  
Image F42850-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42850-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
AR antibody western blot analysis in ZR-75-1 lysate
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P10275
Applications Western blot : 1:1000
Limitations This AR antibody is available for research use only.
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Description

The androgen receptor, also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. It is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.
The main function of the AR is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. [Wiki]

Application Notes

Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 475-504 from the human protein was used as the immunogen for this AR antibody.

Storage

Aliquot the AR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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