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Home >> Antibodies >> AR Antibody

AR Antibody (F42684)

  Catalog No Formulation Size Price (USD)  
Image F42684-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42684-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
AR antibody western blot analysis in (1) NCI-H292, and (1) NCI-H460 lysate. Predicted molecular weight ~99kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Primate
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P10275
Applications Western blot : 1:1000
Limitations This AR antibody is available for research use only.
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Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].

Application Notes

Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 282-309 from the human protein was used as the immunogen for this AR antibody.

Storage

Aliquot the AR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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