AqCbl reductase Antibody / Aquacobalamin reductase / MTRR (RQ8878)

Description

AqCbl reductase, also known as aquacobalamin reductase, is a key enzyme involved in the intracellular metabolism of cobalamin (vitamin B12). It catalyzes the reduction of aquacobalamin to cob(II)alamin, a critical step in the conversion of dietary cobalamin into its biologically active cofactor forms--methylcobalamin and adenosylcobalamin. These active forms are essential for proper DNA synthesis, red blood cell formation, and neurological function. AqCbl reductase ensures that cobalamin is maintained in a reduced state, facilitating its uptake and utilization in various metabolic pathways.

Dysregulation of AqCbl reductase activity can disrupt cobalamin homeostasis and is associated with metabolic disorders, including methylmalonic acidemia and homocystinuria. Given its pivotal role in cobalamin processing, AqCbl reductase has emerged as a critical marker in studies of vitamin B12 metabolism and related diseases. Researchers have also explored its function in oxidative stress responses and mitochondrial health.

The AqCbl reductase antibody enables specific detection of this enzyme in biological samples, supporting studies of cobalamin-dependent metabolic pathways. It is widely used in western blot, immunohistochemistry, and ELISA applications to investigate tissue-specific expression patterns and disease-related changes. With proven performance and high specificity, the AqCbl reductase antibody is an indispensable tool for scientists exploring vitamin B12 metabolism. Incorporating the AqCbl reductase antibody into your research workflow provides valuable insights into the regulation and function of this essential metabolic enzyme.

Application Notes

Optimal dilution of the AqCbl reductase antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids L7-S698) was used as the immunogen for the AqCbl reductase antibody.

Storage

After reconstitution, the AqCbl reductase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.