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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Clusterin (CLU), also known as Apolipoprotein J, is a secreted glycoprotein that plays a key role in neurodegeneration, protein aggregation, and amyloid metabolism within the central nervous system. Apolipoprotein J antibody is widely used to study this proteinâs involvement in neurological disease processes, where it functions as an extracellular chaperone that regulates aggregation and clearance of misfolded proteins. Its activity is particularly relevant in the context of amyloid-beta deposition and neuroinflammatory signaling.
Apolipoprotein J Antibody / Neurodegeneration and Amyloid Marker, also referred to as Clusterin antibody, CLU antibody, or APO-J antibody in the literature, enables detection of this protein in pathways associated with neurodegeneration and proteostasis imbalance. Clusterin is frequently upregulated in response to neuronal stress, injury, and inflammation, where it binds aggregation-prone proteins and influences their solubility, transport, and clearance. This stress-associated upregulation distinguishes its role in disease from its baseline physiological function.
Functionally, Apolipoprotein J interacts with amyloid-beta peptides and other misfolded proteins, forming soluble complexes that reduce aggregation and cytotoxicity. It also participates in clearance pathways through interactions with extracellular receptors and transport systems, influencing deposition and removal of protein aggregates. Apolipoprotein J antibody is therefore valuable for studying amyloid plaque dynamics, protein aggregation, and clearance mechanisms in neurodegenerative diseases such as Alzheimerâs disease.
Clusterin expression is elevated in diseased brain tissue and is often localized to regions of neuronal damage, inflammation, and protein accumulation. In addition to its chaperone activity, it modulates complement activation and immune signaling pathways, linking neurodegeneration with inflammatory responses. This dual role in proteostasis and immune modulation makes Apolipoprotein J a multifaceted marker of disease progression in neurological disorders.
Subcellularly, Apolipoprotein J is synthesized in the endoplasmic reticulum and secreted into the extracellular space, where it accumulates in the tissue microenvironment. Post-translational processing produces glycosylated and cleaved forms that may be detected as multiple bands in western blot analysis. In immunohistochemistry, staining is typically observed in cytoplasmic and extracellular regions, often associated with areas of protein aggregation or tissue remodeling.
This Apolipoprotein J antibody is supported by immunohistochemistry and western blot data demonstrating detection of Clusterin in relevant biological samples, along with protein microarray specificity validation confirming selective binding. Together, these features support its use in studies of neurodegeneration, amyloid biology, and inflammatory signaling in the central nervous system.
This antibody is part of a broader range of Clusterin antibody products supporting research into chaperone function, stress response, and disease biology.
Optimal dilution of the Apolipoprotein J Antibody / Neurodegeneration and Amyloid Marker should be determined by the researcher.
A portion of amino acids 150-300 was used as the immunogen for the Apolipoprotein J antibody.
Aliquot the Apolipoprotein J antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Clusterin antibody, CLU antibody, APO-J antibody, Apolipoprotein J protein antibody, Amyloid-associated clusterin antibody
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