- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Apolipoprotein D Antibody [clone APOD/3413] (V9532)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9532-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V9532-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9532SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c, kappa |
| Clone Name | APOD/3413 |
| Purity | Protein A/G affinity |
| UniProt | P05090 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Apolipoprotein D Antibody is available for research use only. |
|
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Apolipoprotein D Antibody targets APOD, a secreted glycoprotein and member of the lipocalin superfamily. Unlike many classical apolipoproteins, Apolipoprotein D is structurally related to lipocalins, proteins characterized by their ability to bind small hydrophobic molecules. APOD is expressed in a variety of tissues and has been studied in lipid transport, cellular lipid homeostasis, oxidative stress responses and nervous system biology. Clone APOD/3413 is a mouse monoclonal antibody directed against human APOD.
Apolipoprotein D can associate with lipoprotein particles and bind hydrophobic ligands, including arachidonic acid and other lipid molecules. These properties have connected the protein with lipid transport and the regulation of lipid-associated cellular processes. Its lipocalin structure distinguishes APOD from several other apolipoproteins and provides a molecular basis for its ligand-binding activity. An Apolipoprotein D Antibody can support investigation of the expression and distribution of this lipid-binding protein in cells and tissues.
APOD has also been investigated in cellular responses to oxidative stress. Its expression can change following tissue injury and under conditions associated with increased oxidative damage. Studies suggest that Apolipoprotein D may participate in mechanisms that limit lipid peroxidation and help maintain membrane lipid homeostasis. These functions have generated particular interest in aging and nervous system research, where oxidative damage and altered lipid metabolism can influence cellular function.
Changes in APOD expression have additionally been reported in cancer and other disease settings. The protein has been studied in relation to cellular proliferation, differentiation and tumor-associated phenotypes, although its biological effects can vary depending on tissue and cellular context. Together, its lipid-binding properties and associations with cellular stress make Apolipoprotein D relevant to research spanning metabolism, cell biology and disease.
Clone APOD/3413 has been evaluated for target specificity using a HuProt protein microarray containing more than 19,000 full-length human proteins. In this analysis, the Z-score represents antibody signal strength in standard deviations above the mean array signal, while the S-score measures the difference between the intended target Z-score and the next-ranked signal and therefore reflects relative target specificity. NSJ Bioreagents provides APOD/3413 for research use. An Apolipoprotein D Antibody can support studies of lipid binding, lipid transport, cellular stress responses and APOD-associated biology.
For broader research into APOD function, lipid transport and lipocalin biology, see our APOD Antibody / Lipocalin Family Protein Antibody page.
Optimal dilution of the Apolipoprotein D Antibody should be determined by the researcher.
A portin of amino acids 21-119 from the human protein was used as the immunogen for the Apolipoprotein D antibody.
Aliquot the Apolipoprotein D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Apolipoprotein D antibody, APOD antibody, ApoD antibody, Apo-D antibody, GLC antibody
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![Western blot testing of human kidney [A] and liver [B] lysate with APOD antibody at 0.3ug/ml. Predicted molecular weight: ~21/21-33kDa (unmodified/glycosylated).](https://www.nsjbio.com/plp/thumb_image/img-R33889-100UG-1.jpg?v=1787916017 "Western blot testing of human kidney [A] and liver [B] lysate with APOD antibody at 0.3ug/ml. Predicted molecular weight: ~21/21-33kDa (unmodified/glycosylated).")