- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
APOA1 Antibody [Discontinued, view alternative antibodies] (R30352)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30352 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 329 |
|
| Availability | Discontinued |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | P02647 |
| Applications | Western blot : 0.5-1ug/ml |
| Limitations | This APOA1 antibody is available for research use only. |
|
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Apolipoprotein A I is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. It is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase(LCAT) which is responsible for the formation of most plasma cholesteryl esters. APOA1 was also isolated as a prostacyclin(PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, APOA1 overexpression promotes macrophage-specific reverse cholesterol transport.
The stated application concentrations are suggested starting amounts. Titration of the APOA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of human Apolipoprotein A I (YVDVLKDSGRDYVSQFE) was used as the immunogen for this APOA1 antibody (100% homologous in human, mouse and rat).
After reconstitution, the APOA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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