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Home >> Antibodies >> APOA1 Antibody [Discontinued, view alternative antibodies]

APOA1 Antibody [Discontinued, view alternative antibodies] (R30352)

  Catalog No Formulation Size Price (USD)  
Image R30352 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of APOA1 antibody and Lane 1: MCF-7; 2: HeLa; 3: MM453; 4: SMMC-7721; 5: HT1080 cell lysate. Predicted molecular weight ~30kDa.
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P02647
Applications Western blot : 0.5-1ug/ml
Limitations This APOA1 antibody is available for research use only.
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Description

Apolipoprotein A I is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. It is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase(LCAT) which is responsible for the formation of most plasma cholesteryl esters. APOA1 was also isolated as a prostacyclin(PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, APOA1 overexpression promotes macrophage-specific reverse cholesterol transport.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the APOA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human Apolipoprotein A I (YVDVLKDSGRDYVSQFE) was used as the immunogen for this APOA1 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the APOA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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