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Home >> Antibodies >> APEX2 Antibody [Discontinued, view alternative antibodies]

APEX2 Antibody [Discontinued, view alternative antibodies] (R30568)

  Catalog No Formulation Size Price (USD)  
Image R30568 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of APEX2 antibody (0.5ug/ml) and human SMMC-7721 lysate; Predicted molecular weight ~57 kDa.
Availability Discontinued
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q9UBZ4
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This APEX2 antibody is available for research use only.
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Description

Apurinic/apyrimidinic endonuclease like-2 is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene contains 6 exons and is mapped to chromosome Xp11.21. It participates in both nuclear and mitochondrial base excision repair (BER). APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1. The protein plays a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the APEX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human APEX2 (DPSSRCNFFLWSRPS) was used as the immunogen for this APEX2 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the APEX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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