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Home >> Antibodies >> APEX1 Antibody (APE1)

APEX1 Antibody (APE1) (R30567)

  Catalog No Formulation Size Price (USD)  
Image R30567 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of APEX1 antibody and human samples 1: U87; 2: A549; 3: SMMC-7721; 4: HeLa cell lysate. Expected/observed molecular weight: ~38kDa.
Western blot testing of APEX1 antibody and Lane 1: rat brain; 2: mouse brain tissue lysate. Expected/observed molecular weight: ~38kDa.
IHC-P: APEX1 antibody testing of rat intestine tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P27695
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This APE1 antibody is available for research use only.
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Description

APEX1, or Apurinic endonuclease 1 (APE1), which contains probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of the protein was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas. The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the APEX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of human APEX1 (RGLVRLEYRQRWDEA) was used as the immunogen for this APEX1 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the APEX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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