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Home >> Antibodies >> APC Antibody / Adenomatous polyposis coli

APC Antibody / Adenomatous polyposis coli (F47209)

  Catalog No Formulation Size Price (USD)  
Image F47209-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F47209-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
APC antibody western blot analysis in mouse heart tissue lysate
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P25054
Applications Western blot : 1:1000
Limitations This APC antibody is available for research use only.
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Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Application Notes

Titration of the APC antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1148-1176 from the human protein was used as the immunogen for this APC antibody.

Storage

Aliquot the APC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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