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Home >> Antibodies >> Anti-SOX2 Antibody

Anti-SOX2 Antibody (F52993)

  Catalog No Formulation Size Price (USD)  
Image F52993-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F52993-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of lysate from human NCCIT, mouse F9 cell line (left to right) using anti-SOX2 antibody at 1:1000 for each lane.
Availability 1-3 business days
Species Reactivity Human, Mouse
Predicted Reactivity Chicken
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P48431
Localization Cytoplasmic, nuclear
Applications Western blot : 1:1000
Limitations This anti-SOX2 antibody is available for research use only.
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Description

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Application Notes

Titration of the anti-SOX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This anti-SOX2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 282-316 amino acids from the C-terminal region of human SOX2.

Storage

Aliquot the anti-SOX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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