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Home >> Antibodies >> Anti-SOX-2 Antibody

Anti-SOX-2 Antibody (F52893)

  Catalog No Formulation Size Price (USD)  
Image F52893-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F52893-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of lysate from human NCCIT, mouse F9 cell line (left to right) using anti-SOX-2 antibody at 1:1000 for each lane.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P48432
Localization Cytoplasmic, nuclear
Applications Western blot : 1:1000
Limitations This anti-SOX-2 antibody is available for research use only.
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Description

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Application Notes

Titration of the anti-SOX-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This anti-SOX-2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 6~39 amino acids from the N-terminal region of mouse Sox2.

Storage

Aliquot the anti-SOX-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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