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Home >> Antibodies >> Anti-p21 Antibody

Anti-p21 Antibody (F52199)

  Catalog No Formulation Size Price (USD)  
Image F52199-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F52199-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Anti-p21 antibody western blot analysis in mouse NIH3T3 lysate
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P39689
Applications Western blot : 1:1000
Limitations This anti-p21 antibody is available for research use only.
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Description

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Application Notes

Titration of the anti-p21 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 126-154 from the mouse protein was used as the immunogen for this anti-p21 antibody.

Storage

Aliquot the anti-p21 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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