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Home >> Antibodies >> Anti-LGR5 Antibody

Anti-LGR5 Antibody (F48167)

  Catalog No Formulation Size Price (USD)  
Image F48167-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F48167-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Anti-LGR5 antibody western blot analysis in HL-60 lysate
IHC analysis of FFPE human brain tissue stained with anti-LGR5 antibody
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt O75473
Applications IHC (Paraffin) : 1:10-1:50
Western blot : 1:1000
Limitations This anti-LGR5 antibody is available for research use only.
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Description

LGR5/GPR49 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]

Application Notes

Titration of the anti-LGR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 605-638 from the human protein was used as the immunogen for this anti-LGR5 antibody.

Storage

Aliquot the anti-LGR5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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