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Home >> Antibodies >> Anti-IgA Antibody

Anti-IgA Antibody [clone HISA43] (V2617)

  Catalog No Formulation Size Price (USD)  
Image V2617-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V2617-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V2617SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human tonsil with Anti-IgA antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Anti-IgA antibody (clone HISA43) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name HISA43
Purity Protein G affinity chromatography
UniProt P01876 , P01877
Localization Cytoplasm, cell surface and secreted
Applications Flow cytometry : 1-2ug/10^6 cells
Immunofluorescence : 1-2ug/ml 30 min RT
Immunohistochemistry (FFPE) : 1-2ug/ml 30 min RT
Limitations This Anti-IgA antibody is available for research use only.
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Description

This mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Application Notes

Optimal dilution of the Anti-IgA antibody should be determined by the researcher.

Immunogen

Purified human IgA was used as the immunogen for the Anti-IgA antibody.

Storage

Store the Anti-IgA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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