- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Anti-Caspase-8 Antibody (large subunit) (R30365)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30365 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | Q14790 |
| Applications | Western blot : 0.5-1ug/ml |
| Limitations | This anti-Caspase-8 antibody is available for research use only. |
|
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Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases including CASP3/4/6/7/9/10. [UniProt]
The stated application concentrations are suggested starting points. Titration of the anti-Caspase-8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 240-259 (DKVYQMKSKPRGYCLIINNH-human) were used as the immunogen for this anti-Caspase-8 antibody. This sequence is from the large subunit.
After reconstitution, the anti-Caspase-8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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