- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Anti-Androgen Receptor Antibody [clone 549CT16.1.4] (F40398)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F40398-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F40398-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgA |
| Clone Name | 549CT16.1.4 |
| Purity | Purified |
| UniProt | P10275 |
| Applications | Western blot : 1:100-1:250 |
| Limitations | This anti-Androgen Receptor antibody is available for research use only. |
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Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of AR represses AR-dependent transcription.
Titration of the anti-Androgen Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Purified His-tagged protein fragment was used to produced this monoclonal anti-Androgen Receptor antibody.
Aliquot the anti-Androgen Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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