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Home >> Antibodies >> ANPEP Antibody

ANPEP Antibody [clone 505CT12.1.2] (F40379)

  Catalog No Formulation Size Price (USD)  
Image F40379-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F40379-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
ANPEP antibody western blot analysis in HepG2 lysate
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a
Clone Name 505CT12.1.2
Purity Purified
UniProt P15144
Applications Western blot : 1:100-1:250
Limitations This ANPEP antibody is available for research use only.
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Description

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Application Notes

Titration of the ANPEP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 156-184 from the human protein was used as the immunogen for this ANPEP antibody.

Storage

Aliquot the ANPEP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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