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Home >> Antibodies >> Annexin VIII Antibody [Discontinued, view replacements]

Annexin VIII Antibody [Discontinued, view replacements] (R30573)

  Catalog No Formulation Size Price (USD)  
Image R30573 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 285
Western blot testing of Annexin VIII antibody and Lane 1: Jurkat; 2: SMMC-7721; 3: Jurkat; 4: COLO320 cell lysate. Predicted molecular weight ~37 kDa.
Availability Discontinued
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P13928
Applications Western blot : 0.5-1ug/ml
Limitations This Annexin VIII antibody is available for research use only.
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Description

Human Annexin VIII was originally identified from a 2-kb cDNA transcript containing an open reading frame that encoded a 327-amino acid protein termed vascular anticoagulant beta. It is a minor annexin in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia. The gene is mapped to chromosome 10q11.2 by fluorescence in situ hybridization. Affected human promyelocytes contain a nonrandom chromosomal translocation breakpoint involving chromosomes 15 and 17 and creating 2 hybrid mRNA fusion products and chimeric proteins. These involve the retinoic acid receptor-alpha geneon chromosome 17q12 and the promyelocytic leukemia gen on chromosome 15q22. Strong overexpression of Annexin VIII in this disorder could be repressed by retinoic acid-induced expression of the RARA gene product.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Annexin VIII antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of human Annexin VIII (PYRYEAKELHDAMKGL) was used as the immunogen for this Annexin VIII antibody.

Storage

After reconstitution, the Annexin VIII antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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