- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Angiotensin converting enzyme (ACE), also known as CD143 or ACE1, is a membrane-associated metalloprotease that plays a central role in the regulation of vascular function and blood pressure through the renin-angiotensin system. The Angiotensin Converting Enzyme Antibody / ACE Endothelial Cell Surface Enzyme Antibody is designed to detect this key enzyme in tissues where endothelial biology and peptide processing are critical. ACE is encoded on chromosome 17q23 and is primarily expressed on the surface of vascular endothelial cells, where it functions as a dipeptidyl carboxypeptidase. This antibody is part of a collection of Human Protein Microarray validated antibodies that have been screened for specificity across thousands of proteins.
The Angiotensin Converting Enzyme antibody, also referred to as ACE antibody, ACE1 antibody, and CD143 antibody in the literature, recognizes a protein that is localized predominantly to the plasma membrane of endothelial and epithelial cells. ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and also inactivates bradykinin, thereby regulating vascular tone, fluid balance, and inflammatory signaling. This dual enzymatic role makes ACE a central component of cardiovascular physiology and a key target in hypertension research.
This Angiotensin Converting Enzyme Antibody / ACE Endothelial Cell Surface Enzyme Antibody is uniquely positioned for studies of vascular biology and endothelial cell function. In immunohistochemistry, ACE is typically observed as membranous staining along vascular endothelium and in select epithelial compartments, reflecting its cell surface localization. This pattern enables clear visualization of blood vessels and tissue architecture, making ACE a useful marker for endothelial identification and vascular integrity.
In addition to its physiological role, ACE is implicated in a range of pathological conditions, including hypertension, cardiovascular disease, and inflammatory disorders. Altered ACE expression has also been observed in certain cancers, where vascular remodeling and tumor-associated angiogenesis are involved. Detection of ACE expression can therefore provide insight into vascular structure, endothelial activation, and disease-associated changes in tissue microenvironments.
The mouse monoclonal clone ACE/3764 provides consistent and specific detection of ACE, supported by protein microarray specificity validation data demonstrating selective binding to the intended target. This Angiotensin Converting Enzyme Antibody / ACE Endothelial Cell Surface Enzyme Antibody is suitable for detecting ACE expression in research applications focused on vascular biology, endothelial cell function, and peptide processing pathways. Its performance supports detailed evaluation of ACE localization and expression across normal and disease-associated tissues.
This antibody supports investigation of endothelial cell biology, vascular structure, and renin-angiotensin system activity involving ACE.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the Angiotensin Converting Enzyme Antibody / ACE Endothelial Cell Surface Enzyme Antibody should be determined by the researcher.
Full-length recombinant human protein was used as the immunogen for the Angiotensin Converting Enzyme antibody.
Aliquot the Angiotensin Converting Enzyme antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
ACE antibody, Angiotensin converting enzyme antibody, ACE1 antibody, CD143 antibody, ACE endothelial marker antibody
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