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Home >> Antibodies >> Angiotensin Converting Enzyme 2 Antibody / ACE2

Angiotensin Converting Enzyme 2 Antibody / ACE2 [clone ACE2/8748R] (V5346)

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  Catalog No Formulation Size Price (USD)  
Image V5346-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5346-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5346SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human small intestine tissue with Angiotensin Converting Enzyme 2 antibody (clone ACE2/8748R) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human small intestine tissue with Angiotensin Converting Enzyme 2 antibody (clone ACE2/8748R) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Angiotensin Converting Enzyme 2 antibody (clone ACE2/8748R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name ACE2/8748R
Purity Protein A/G affinity
UniProt Q9BYF1
Localization Cell membrane, Secreted
Applications ELISA (Order BSA-free format for coating) :
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This Angiotensin Converting Enzyme 2 antibody is available for research use only.
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Description

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Application Notes

Optimal dilution of the Angiotensin Converting Enzyme 2 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 705-805) from the human protein was used as the immunogen for the Angiotensin Converting Enzyme 2 antibody.

Storage

Aliquot the Angiotensin Converting Enzyme 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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