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Home >> Antibodies >> Androgen Receptor Antibody

Androgen Receptor Antibody [clone HD-1] (RQ5317)

  Catalog No Formulation Size Price (USD)  
Image RQ5317 Antibody in PBS with 0.02% sodium azide and 50% glycerol 100 ug 359
Western blot testing of human 1) T-47D and 2) LNCaP cell lysate with Androgen Receptor antibody. Predicted molecular weight ~99 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name HD-1
Purity Affinity purified
UniProt P10275
Applications Western blot : 1:500-1:2000
Limitations This Androgen Receptor antibody is available for research use only.
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Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [RefSeq]

Application Notes

Optimal dilution of the Androgen Receptor antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Androgen Receptor was used as the immunogen for the Androgen Receptor antibody.

Storage

Store the Androgen Receptor antibody at -20oC.

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