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Home >> Antibodies >> Androgen Receptor Antibody [Discontinued, view alternative antibodies]

Androgen Receptor Antibody [Discontinued, view alternative antibodies] (R30569)

  Catalog No Formulation Size Price (USD)  
Image R30569 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Androgen Receptor antibody and 1) human HeLa and 2) mouse pancreas lysate. Expected molecular weight: 99-110 kDa.
IHC-P: Androgen Receptor antibody testing of human prostate cancer tissue. HIER: steamed with pH6 citrate buffer.
Availability Discontinued
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P10275
Localization Nuclear
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Immunocytochemistry : 0.5-1ug/ml
Limitations This Androgen Receptor antibody is available for research use only.
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Description

The AR gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. Androgen receptor functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Application Notes

The stated application concentrations are suggested starting points. Titration of the Androgen Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human Androgen Receptor (LKNQKFFDELRMNYIKE) was used as the immunogen for this Androgen Receptor antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the Androgen Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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