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Home >> Antibodies >> ALK Antibody / Anaplastic Lymphoma Kinase

ALK Antibody / Anaplastic Lymphoma Kinase [clone ALK/1032] (V8812)

  Catalog No Formulation Size Price (USD)  
Image V8812-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 499
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V8812-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 219
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V8812SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 499
Western blot testing of a recombinant ALK partial protein using Anaplastic Lymphoma Kinase antibody (clone ALK/1032).
SDS-PAGE analysis of purified, BSA-free Anaplastic Lymphoma Kinase antibody (ALK/1032) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name ALK/1032
Purity Protein A/G affinity
UniProt Q9UM73
Localization Cytoplasmic, Nuclear
Applications Western blot : 1-2ug/ml
Limitations This Anaplastic Lymphoma Kinase antibody is available for research use only.
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Description

The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.

Application Notes

Optimal dilution of the Anaplastic Lymphoma Kinase antibody should be determined by the researcher.

Immunogen

A portion of amino acids 220-335 was used as the immunogen for the Anaplastic Lymphoma Kinase antibody.

Storage

Aliquot the Anaplastic Lymphoma Kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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