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Home >> Antibodies >> Amyloid beta Precusor Protein Antibody

Amyloid beta Precusor Protein Antibody (F51499)

  Catalog No Formulation Size Price (USD)  
Image F51499-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F51499-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of Amyloid beta precusor protein antibody in T47D lysate. Predicted molecular weight 79~120kDa depending on glycosylation level.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Pig, Primate, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P05067
Applications Western blot : 1:1000
Limitations This Amyloid beta precusor protein antibody is available for research use only.
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Description

APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Application Notes

Titration of the Amyloid beta precusor protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.

Storage

Aliquot the Amyloid beta precusor protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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