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Home >> Antibodies >> Amyloid beta Antibody / APP

Amyloid beta Antibody / APP [clone APP/3667] (V5427)

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  Catalog No Formulation Size Price (USD)  
Image V5427-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5427-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5427SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human brain tissue with Amyloid beta antibody (clone APP/3667). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human brain tissue with Amyloid beta antibody (clone APP/3667). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Amyloid beta antibody (clone APP/3667) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name APP/3667
Purity Protein A/G affinity
UniProt P05067
Localization Cell membrane, cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Amyloid beta antibody is available for research use only.
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Description

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the b-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid b/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Application Notes

Optimal dilution of the Amyloid beta antibody should be determined by the researcher.

Immunogen

A recombinant fragment (within amino acids 500-700) of human APP protein was used as the immunogen for the Amyloid beta antibody.

Storage

Aliquot the Amyloid beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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