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Home >> Antibodies >> Amyloid Beta Antibody

Amyloid Beta Antibody [clone APP/3345] (V8733)

  Catalog No Formulation Size Price (USD)  
Image V8733-100UG 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 429
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V8733-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V8733SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
Immunofluorescent staining of PFA-fixed human U-87 MG cells with Amyloid Beta antibody (clone APP/3345, green) and Reddot nuclear stain (red).
IHC staining of FFPE human brain with Amyloid Beta antibody (clone APP/3345). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Amyloid Beta antibody (clone APP/3345). These results demonstrate the foremost specificity of the APP/3345 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free Amyloid Beta antibody (clone APP/3345) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2c, kappa
Clone Name APP/3345
Purity Protein G affinity chromatography
UniProt P05067
Localization Membrane
Applications Immunofluorescence : 1-2ug/ml
Flow cytometry : 1-2ug/million cells
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This Amyloid Beta antibody is available for research use only.
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Description

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Application Notes

Optimal dilution of the Amyloid Beta antibody should be determined by the researcher.

Immunogen

A portion of amino acids 578-680 from the human protein was used as the immunogen for the Amyloid Beta antibody.

Storage

Store the Amyloid Beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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